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Client mid-session in an XR chamber, cabin display reading -213°F beside a thermal image

Clinical research

The research behind cold

Cold therapy has a real scientific literature behind it. This library collects published studies on whole-body cryotherapy and cold exposure, and shows how the science shapes the machines.

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The library

Clinical studies on cryotherapy

Read the published research on whole-body cryotherapy below. These studies are available in their entirety and are not produced, sponsored, or solicited by Cryo Innovations.

39 published studies

Read the studies

Each link opens the study at its publisher, in a new tab.

  1. Mental state and quality of lifeWhole-body cryotherapy on various parameters of the mental state of patients depending on their age, gender, and diagnosed illnessresearchgate.net
  2. Depressive and anxiety disordersAssess the efficacy of Whole-Body Cryotherapy as an experimental, adjunctive method of treating depressive and anxiety disordersncbi.nlm.nih.gov
  3. Combat obesity: triggering thermogenesisSingle sessions of tissue cryotherapy lead to significant loss of tissue volume in the time frame of hoursncbi.nlm.nih.gov
  4. Whole-body cryotherapy in athletesEffectiveness of Whole Body Cryotherapy in relieving symptomatology of the whole set of inflammatory conditions that could affect an athletencbi.nlm.nih.gov
  5. Tennis playersFive-Day Whole-Body Cryostimulation, Blood Inflammatory Markers, and Performance in High-Ranking Professional Tennis Playersmedia.wix.com
  6. RunnersEffects of Whole-Body Cryotherapy vs. Far-Infrared vs. Passive Modalities on Recovery from Exercise-Induced Muscle Damage in Highly Trained Runnersmedia.wix.com
  7. RehabilitationWhole-Body Cryotherapy in rehabilitation of patients with rheumatoid diseases: pilot studyncbi.nlm.nih.gov
  8. Fight obesityCold exposure leads to marked changes in the gut microbiota compositioncell.com
  9. AthletesWhole-Body Cryotherapy in athletesncbi.nlm.nih.gov
  10. Whole body treatmentThe effects of prolonged whole-body cryostimulation treatment with different amounts of sessions on chosen pro- and anti-inflammatory cytokines levelsncbi.nlm.nih.gov
  11. Whole body cryotherapyEffects of Whole-Body Cryotherapy and melatonin supplementation on total antioxidative status and some antioxidative enzymes in multiple sclerosis patientsncbi.nlm.nih.gov
  12. Body reactionsTime-course of changes in inflammatory response after Whole-Body Cryotherapy multi exposures following severe exercisencbi.nlm.nih.gov
  13. SportsBeneficial Effects of Whole-Body Cryotherapy on Sport Haemolysisjhse.ua.es
  14. OsteoporosisCryotherapy in Osteoporosisncbi.nlm.nih.gov
  15. Whole body reactionsThermal, Circulatory and Neuromuscular Responses to Whole-Body Cryotherapyjultika.oulu.fi
  16. BloodCryotherapy decreases histamine levels in the blood of patients with rheumatoid arthritisncbi.nlm.nih.gov
  17. NeuromuscularNeuromuscular adaptation after repeated exposure to whole-body cryotherapy (-110°C)pubmed.ncbi.nlm.nih.gov
  18. AthletesEffects of the whole-body cryotherapy on NTproBNP, hsCRP and troponin I in athletessciencedirect.com
  19. Men's healthDo sessions of cryostimulation have influence on white blood cell count, level of IL6, and total oxidative and antioxidative status in healthy men?ncbi.nlm.nih.gov
  20. CryostimulationWhole-body cryostimulation in kayaker women: A study of the effect of cryogenic temperatures on oxidative stress after exercisencbi.nlm.nih.gov
  21. Effects of whole body cryoEffect of whole-body cryotherapy on the levels of some hormones in professional soccer playerspubmed.ncbi.nlm.nih.gov
  22. Mental healthThe influence of whole body cryotherapy on mental healthncbi.nlm.nih.gov
  23. Whole body cryotherapyWhole-body cryotherapy in patients with inflammatory rheumatic disease. A prospective study.ncbi.nlm.nih.gov
  24. Anxiety treatmentWhole-body cryotherapy as adjunct treatment of depressive and anxiety disordersncbi.nlm.nih.gov
  25. CryotherapyEvaluation of effectiveness of whole-body cryotherapy in patients with tinnitusncbi.nlm.nih.gov
  26. Inflammatory rheumatic diseasesSerial whole-body cryotherapy in the criostream for inflammatory rheumatic diseasesncbi.nlm.nih.gov
  27. CryotherapyThe impact of whole-body cryotherapy on parameters of spinal mobility in patients with ankylosing spondylitisncbi.nlm.nih.gov
  28. Thermal imagingMonitoring of whole body cryotherapy effects by thermal imagingncbi.nlm.nih.gov
  29. ArthritisEffectiveness of different cryotherapies on pain and disease activity in active rheumatoid arthritis. A randomized single blind controlled trial.ncbi.nlm.nih.gov
  30. Healthy womenEffects of repeated whole-body cold exposures on serum concentrations of growth hormone, thyrotropin, prolactin and thyroid hormones in healthy womenncbi.nlm.nih.gov
  31. Anxiety reliefCan short-term exposure to extremely low temperatures be used as an adjuvant therapy in the treatment of affective and anxiety disorders?ncbi.nlm.nih.gov
  32. Healthy femalesEffects of long-term whole-body cold exposures on plasma concentrations of ACTH, beta-endorphin, cortisol, catecholamines and cytokines in healthy femalesncbi.nlm.nih.gov
  33. CryostimulationAcute effect of a single whole-body cryostimulation on prooxidant-antioxidant balance in blood of healthy, young mensciencedirect.com
  34. Aerobic and anaerobicInfluence of the ten sessions of the whole body cryostimulation on aerobic and anaerobic capacityncbi.nlm.nih.gov
  35. CryostimulationThe effect of whole-body cryostimulation on the prooxidant-antioxidant balance in blood of elite kayakers after trainingncbi.nlm.nih.gov
  36. Heart rateHeart rate variability in women exposed to very cold air (-110°C) during whole-body cryotherapysciencedirect.com
  37. Cryostimulation treatmentChanges in lipid profile in response to three different protocols of whole-body cryostimulation treatmentsncbi.nlm.nih.gov
  38. Multiple sclerosis patientsEffects of whole-body cryotherapy on a total antioxidative status and activities of antioxidative enzymes in blood of depressive multiple sclerosis patientsncbi.nlm.nih.gov
  39. Whole body treatmentAssessment of pelvic statics in patients with spinal overload syndrome treated in whole-body cryotherapyncbi.nlm.nih.gov

From paper to floor plan

The science is the argument. The machine is the answer.

See how a 2–3 minute whole-body session actually runs, on the hardware built for it.

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The engineering response

What the research demanded of the hardware

Extreme cold deserves engineering respect. The safety systems on every XR machine are the practical answer to what the literature says about doing cold properly: controlled exposure, monitored clients, and a hard stop always within reach.

Fingerprint authorizationFingerprint authorization
Pulse sensorPulse sensor
Door alarmDoor alarm
Emergency stopEmergency stop
Fail-safe unlockFail-safe unlock
LN2 valve regulationLN2 valve regulation
PPE for chamber operatorsPPE for chamber operators
XR Cryo Kiosk operator touchscreen

Monitored, every second

Controlled exposure by design

Sessions are short by protocol, 2–3 minutes whole-body, and the operator screen holds live cabin status the entire time. Thermal imaging, pulse sensing and fail-safe unlocks keep the exposure controlled from the first second to the last.

Put the science to work

Tell us the clients you serve and a specialist will walk you through how operators apply cold in your setting, and which machine carries it.

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